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Minggu, 14 April 2013

Facts Concerning Peptides The Synthesis of Peptide

By Armand Zeiders


Biotech firms are often tasked with jobs such as custom protein expression, N-terminal sequencing services and often custom peptide synthesis. The latter has many important applications, but it is complicated for those outside the scientific community to understand. Here is a brief explanation that may be of help to those wanting to know more about peptides and synthesis.

First of all, a peptide is simply a compound formed when amino acids become linked. These are chains of amino acids, and when these chains become long enough, they begin to form proteins. Proteins carry out many essential functions in the body from transportation to reproducing DNA.

When we speak of peptide synthesis, all this means is that peptides are being created. This occurs naturally in all living creatures, and in its natural form, it is called biosynthesis. When it happens in a lab, it is called custom peptide synthesis since we are making specific synthetic peptides. These synthetic peptides are used for studies conducted by a number of scientists, including biochemists, neurobiologists and pharmacologists.

One reason why custom peptide synthesis is important is that scientists use these peptides to study the structures of certain proteins. This can help them find clues to explain how certain diseases form and possibly how to stop a disorder from progression, develop early tests for diseases and possibly create vaccines to prevent diseases from occurring in the first place. There are many diseases being studied that will benefit from these studies, including debilitating neurological disorders such as Parkinson's disease, Alzheimer's disease and other similar medical issues.

Peptides are used in the production of monoclonal antibodies as well as polyclonal antibodies. The monoclonal antibodies are all identical and created from the same cell. Custom monoclonal antibody production is helpful to scientists who are trying to create tests that can screen for diseases. Early screening for diseases can be a huge benefit and can mean that treatments can be given as soon as possible, which can slow the progression of a disease.

Where mono means one and pertains to one specific antibody, the custom polyclonal antibodies are created from more than one single source. You can use these polyclonals for many different studies, including function studies, epitope mapping, antibody-antigen interaction studies and receptor studies. Experimental treatments for viruses such as deadly strains of Ebola are another use for polyclonal antibodies, and they also are used to create antiserums.




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